INDICATORS OF ENDOGENOUS INTOXICATION IN THE MODEL OF BURN INJURY IN CORRECTION WITH CHITOSAN DERIVATIVES

Burns and burn injury is one of the main problems of modern medicine due to high mortality and disability. Wound healing is the most important general biological, medical, and social problem, which remains relevant to this day. The aim of the work was to study the indicators of endogenous intoxication on the model of burn injury in the correction with chitosan derivatives. In this work, Bombyx mori chitosan-based gels were used; the thermal burn model was reproduced on 120 outbred male rats weighing 140–160 g. The preparations were applied at a dosage of 1 mg/kg of animal body weight to a skin area with a thermal burn. An analysis of the data obtained during the study of the effect of several dosage forms of chitosan (solution, gel, film) on the process of skin wound healing in rats and rabbits showed that