CORRECTIVE EFFECT OF GASTRIC LONGITUDINAL RESECTION IN PATIENTS WITH MORBID OBESITY ON HEMOSTASIS INDICATORS DISORDERS
Keywords:
morbid obesity, hemostasis parameters, sleeve gastrectomy.Abstract
Obesity, according to expert evidence, leads to a risk of cardiovascular diseases by 4 times and mortality from cancer by 2 times. Evaluation of hemostasis disorders in patients with morbid obesity and study of the significance of the practice of longitudinal resection of the stomach. From 2019 to 2022 years in our clinic were performed 231 metabolic and bariatric surgeries, including 82 minigastric bypasses (MGS) and 149 sleeve resection (SG). Over the years, SG was performed in 149 patients with different body mass index. 84 (56,3%) patients suffering from morbid obesity had grade III obesity, 65 (43,7%) had grade II obesity. The analyzes performed showed that patients suffering from morbid obesity have a tendency to hypercoagulability in vascular-platelet and coagulation hemostasis.
In morbid obesity, depending on its severity, statistically significant disturbances in the value of hemostasis parameters of patients were observed, a moderate positive association with BMI was revealed; genetic predisposition, as well as in patients with concomitant diseases such as diabetes mellitus.
References
Аметов А.С. Сахарный диабет 2-го типа: проблемы и решения.7– М.: ГЭОТАР-Медиа, 2012.7– 704 с.
Седлецкий Ю.И. Хирургическое лечение метаболического синдрома.– СПб.: ЭЛБИ-СПб, 2014.– 192с.
Тешаев О.Р., Муродов А.С., Мавлянов О.Р. Анализ результатов увеличения резекции желудка у больных морбидным ожирением «Новый день в медицине» 2022.9(47).-С. 165-170 б.
Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007; 357: 753-761. [CrossRef]
Angrisani L, Santonicola A, Iovino P, Vitiello A, Higa K, Himpens J, Buchwald H, Scopinaro N. IFSO Worldwide Survey 2016: primary, endoluminal, and revisional procedures. Obes Surg. 2018;28(12):3783–3794. doi: 10.1007/s11695-018-3450-2. [PubMed] [CrossRef] [Google Scholar]
Bout-Tabaku S., Gupta R., Jenkins T.M., Ryder J.R., Baughcum A.E., Jackson R.D. Musculoskeletal pain, physical function, and quality of life after bariatric surgery. Pediatrics. 2019 [PMC free article] [PubMed] [Google Scholar]
Carrano FM, Peev MP, Saunders JK, Melis M, Tognoni V, Di Lorenzo N (2020) The role of minimally invasive and endoscopic technologies in morbid obesity treatment: review and critical appraisal of the current clinical practice. Obes Surg 30(2):736– 752. https://doi.org/10.1007/s11695-019-04302-8.
Cresci B, Cosentino C, Monami M, Mannucci E. Metabolic surgery for the treatment of type 2 diabetes: a network metaanalysis of randomized controlled trials. Diabetes Obes Metab. 2020 Apr 3. https://doi.org/10.1111/dom.14045. [Epub ahead of print]
Gagner M, Gumbs A.A., Milone L., Jung E., Goldenberg L., Pomp A. Laparoscopic sleeve gastrectomy for super-super-obese (body mass index >60 kg/m2), Surg Today 2008. ; 38: 399-403 [CrossRef].
Hess DS, Hess DW. Biliopancreatic diversion wit h a duodenal switch. Obes Surg 1998; 8: 267-82
Lee CM, Cirangle PT, Jossart GH. Vertical gastrectomy for morbid obesity in 210 patients: report of two-year results. Surg Endosc 2007; 21: 1810-6.
Levi M, van der Poll T, Schultz M. Infection and inflammation as risk factors for thrombosis and atherosclerosis. Semin Thromb Hemost. 2012;38:506–514.
Levi M, van der Poll T, Schultz M. Infection and inflammation as risk factors for thrombosis and atherosclerosis. Semin Thromb Hemost. 2012;38:506–514.
Moon HS, Kim WW, Oh JH. Results of laparoscopic sleeve gastrectomy (LSG) et 1 year in morbidly obese Korean patients. Obes Surg 2005; 15: 1469-75
Moy J, Pomp A, Dakin G, Parikh M, Gagner M. Laparoscopic sleeve gastrectomy for morbid obesity. Am J Surg 2008; 196: 56- 59 [CrossRef]
Neeland IJ, Poirier P, Després JP (2018) Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management. Circulation 137(13):1391–1406. https:// doi.org/ 10.1161/ CIRCULATIONAHA . 117.029617
Parikh N.I., Pencina M.J., Wang T.J., Lanier K.J., Fox C.S., D’Agostino R.B. Increasing trends in incidence of overweight and obesity over 5 decades. Am. J. Med. 2007;120(3):242–250. [PubMed] [Google Scholar]
Raziel A, Sakran N, Szold A, Teshuva O, Krakovsky M, Rabau O, et al. Mid-term follow-up after laparoscopic sleeve gastrectomy in obese adolescents. Isr Med Assoc J 2014; 16: 37-41.
Review , Ding L, Fan Y, Li H, Zhang Y, Qi D, Tang S, Cui J, He Q, Zhuo C, Liu M (2020) Comparative efectiveness of bariatric surgeries in patients with obesity and type 2 diabetes mellitus: a network metaanalysis of randomized controlled trials. Obes Rev 21(8):e13030. https://doi.org/10.1111/obr.13030 (Epub 2020 Apr 14)
Ruban A, Stoenchev K, Ashrafan H, Teare J (2019) Current treatments for obesity. Clin Med (Lond). 19(3):205–212. https:// doi.org/10.7861/clinmedicine.19-3-205
Samad F, Loskutoff DJ. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med. 1996;2:568–582.
Schiavon CA, Bersch-Ferreira AC, Santucci EV, et al. Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension). Circulation. 2018; 137(11): 1132-1142. https://doi.org/10.1161/CIRCULA-TIONAHA.117.032130.
Sinclair P., Brennan D.J., le Roux C.W. Gut adaptation after metabolic surgery and its influences on the brain, liver and cancer. Nat. Rev. Gastroenterol. Hepatol. 2018;1 [PubMed] [Google Scholar]
Sjostrom L, Narbro K, Sjostrom CD, Karason K, Larsson B, Wedel H, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357: 741-752. [CrossRef]
Sjöström L. Review of key findings from the Swedish Obese Subjects (SOS) study - a prospective controlled interventional trial of bariatric surgery. J Intern Med 2013;273:219-234 [CrossRef]
Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93:359–404.,
Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17:179–188.
