BODY CONDITION IN WOMEN WITH OBESITY AND METABOLIC SYNDROME
Keywords:
obesity, metabolic syndrome, hemostasis, combined oral contraceptives, pregnancy, postmenopause, venous thrombo embolism.Abstract
Today, the spread of obesity has reached epidemic proportions and has led to an increase in morbidity and mortality, including from thrombotic complications. Metabolic syndrome (MS) is characterized by abdominal obesity, impaired glucose metabolism, arterial hypertension, and dyslipidemia. Patients with MS are at high risk of atherothrombosis and cardiovascular events. The problem of hemostasis disorders in women with obesity and MS is relevant and is of significant clinical interest. Hemostatic changes in women with obesity and metabolic syndrome, including hypercoagulability, hypofibrinolysis and platelet dysfunction, play an important role in increasing the risk of cardiovascular morbidity and mortality, as well as venous thromboembolism (VTE). Taking combined oral contraceptives increases the risk of VTE in obese women. During pregnancy and the postpartum period, obesity has become one of the most common causes of VTE. During the postmenopausal period, both the presence of obesity and MS, and the use of oral medications for menopausal hormonal therapy require close attention and monitoring of hemostasis parameters. The review presents the main changes in the hemostatic system in obesity and MS, and also discusses the role of obesity and MS in the development of hemostatic disorders and VTE in women of reproductive age and postmenopause.
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