MODERN VIEW IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS
Keywords:
type 2 diabetes mellitus, insulin resistance, β-cells, dipeptidyl peptidase-4 inhibitor, thiacholidinedione, gliptin.Abstract
The incidence of type 2 diabetes mellitus (T2DM) is very high and continues to grow alarmingly, being the leading cause of mortality in the population. The medical and social significance of T2DM is determined primarily by its severe vascular and neurological complications, which lead to early disability and high mortality, reduced life expectancy and deterioration in its quality. T2DM is characterized by progressive dysfunction of pancreatic β-cells accompanied by the development of insulin resistance. The article discusses the mechanisms of action of hypoglycemic drugs from the group of peroxisome proliferator-activated receptor (PPARγ) agonists - pioglitazone and the group of dipeptidyl peptidase-4 inhibitors - alogliptin. Pioglitazone improves insulin sensitivity through increasing the expression of numerous genes encoding proteins or proteins that modulate glucose and fat metabolism. Alogliptin increases glucose-dependent activity of β-cells with a low risk of hypoglycemia, suppresses increased secretion of glucagon, and has cardiovascular safety. The feasibility of using a fixed combination of pioglitazone and alogliptin has been substantiated, which makes it possible to effectively and safely manage T2DM, simultaneously influencing 10 of 11 pathophysiological disorders that lead to the development of the disease.References
Отамуродов УГ угли, Абдужамбилов АН угли, Сабирова ДШ. Гипертиреоз. Science and Education. 2023;4(5):134-139.
Шухратовна СД, Рустамовна РГ, Нодир Р. Изменения уровня хг в системе мать-плацента-плод при резус несовместимой беременности. Достижения науки и образования. 2020;(10 (64)):91-93.
Хамраев X, Содиков С, Хамраева Д, Собирова Д. Клинико-функциональное состояние печени у больных с сахарным диабетом. ЖПБМ. 2018;(1 (99)):189-191.
Shukhratovna SD, Suratovich OF. МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ КОРЫ НАДПОЧЕЧНИКОВ ПОТОМСТВА КРЫС В ОНТОГЕНЕЗЕ В УСЛОВИЯХ ВНУТРИУТРОБНОГО ВОЗДЕЙСТВИЯ ПЕСТИЦИДОВ ЧЕРЕЗ ОРГАНИЗМ МАТЕРИ (ОБЗОРНАЯ СТАТЬЯ). JOURNAL OF BIOMEDICINE AND PRACTICE. 2023;8(4). Accessed January 12, 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/8217
Мизамова МАК, Эшпулатова ГНК, Эшмуродова ЗНК, Салимова ДЭ. Осложнения акромегалии, связанные со здоровьем, текущие и перспективные варианты лечения. Science and Education. 2023;4(4):187-195.
Нарбаев А, Джураева З, Курбонова Н, Кувондиков Г, Давранова А, Содиков С. Особенности изучения многофакторного управления сахарным диабетом 2 типа. Журнал проблемы биологии и медицины. 2017;(4 (97)):78-79.
Ибрагимов УС, Туракулов ЖТУ, Гуломов ШНУ, Салимова ДЭ. Просвещение пациентов: Гипогликемия (низкий уровень глюкозы в крови) у людей с диабетом. Science and Education. 2023;4(4):226-233.
Содиков С, Каримова Н, Каримова З. Реабилитация больных пожилого возраста сахарным диабетом 2-типа. ЖПБМ. 2017;(4 (97)):105-106.
Хамидова МН, Исматова ИФ, Бердиеров ЖШ, Негматова ГШ, Даминов АТ. САХАРНЫЙ ДИАБЕТ И COVID-19. Eurasian Journal of Medical and Natural Sciences. 2022;2(13):190-204.
Шухратовна СД, Кахрамонович ЮУ, Махмудович КТ. Структурные изменения сосудисто-стромального комплекса щитовидной железы при эутиреоидной и токсических формах зоба. Научный журнал. 2019;(10 (44)):67-69.
Собиржоновна КН, Саллохидинович СС, Акбаровна ОМ. Эпидемиологический Статус И Факторы Риска Сахарного Диабета На Сегодняшний День. Miasto Przyszłości. 2023;32:212-219.
Salimova DE, Daminnov AT. A CLINICAL CASE BASED ON THE EXPERIENCE OF TREATING HYPERTENSION IN A PATIENT WITH TYPE 2 DIABETES MELLITUS, OBESITY AND VITAMIN D DEFICIENCY. Educational Research in Universal Sciences. 2023;2(12):150-154.
Takhirovich DA. ASSESSMENT OF HEARING FUNCTION IN INDIVIDUALS WITH TYPE 2 DIABETES. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(9):124-126.
Qahramonov FA, Amirov BY, Tursunboyeva LI, Daminov AT. Autoimmun tireoidit bilan kasallangan bemorlardagi funksional buzilishlarning differensional diagnostikasida qalqonsimon bez zichligini aniqlash. Science and Education. 2023;4(3):82-86.
Nazira K, Siddikovna TG, Davranovna DA, Takhirovich DA, Tulkinovich OS. Cardiovascular complications in patients who have had covid on the background of diabetes mellitus 2. 1. 2021;2(3):37-41.
Choriyev S, Gadoeva Z, Mardonova F, Jurakulov F, Hafizov S, Daminov AT. Changes in the thyroid gland in the long period after a new coronavirus infection. Science and Education. 2023;4(12):102-106.
Kamalov T, Bahriev N, Yuldashev U, Sabirova D. CLINICAL AND HORMONAL CHARACTERISTICS OF PRIMARY HYPOGONADISM IN PRESCHOOL BOYS. MedFarm. 2019;10(9). doi:10.32743/2658-4093.2019.9.10.188
Daminov A, Khaydarov O, Hasanova M, Abdukakhorova R. COMPLICATIONS OF GLUCOCORTICOID THERAPY IN PATIENTS DIABETES SURVIVED COVID-19. Евразийский журнал медицинских и естественных наук. 2023;3(4):197-200.
Takhirovich DA, Corners SJA, Shukhratovna NG, Shukhratovna SG, Zaynuddinovna MG. COURSE OF COVID-19 IN PATIENTS WITH DIABETES MELLITUS. Web of Scientist: International Scientific Research Journal. 2022;3(02):73-76. doi:10.17605/OSF.IO/B6FU2
Shukhratovna NG, Erkinovna SD, Suxrobovna XM, Ikromovna AZ. DIABETES MELLITUS, ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION. PEDAGOG. 2022;5(5):381-386.
O‘g‘li SOS, O‘g‘li RSO, Taxirovich DA. DIFFUZ TOKSIK BUQOQ. Лучшие интеллектуальные исследования. 2023;4(1):131-133.
G.Sh N, D.e S, Oybekovma XS, Qamariddinovna XA, O‘g‘li BJA. ENDOCRINE GLANDS, STRUCTURE, AGE FEATURES, FUNCTIONS. PEDAGOG. 2022;5(5):341-345.
Sobirjonovna KN. FACTORS DETERMINING THE CLINICAL SIGNIFICANCE OF DEPIPTIDYL PEPTIDASE 4 INHIBITORS IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS. World Bulletin of Public Health. 2022;8:67-72.
Daminov AT, Djabbarova D, Abduvohidova N, Furkatova D, Farxodova S, Ibragimova P. Features of bone tissue remodeling in patients with type 2 diabetes mellitus. Science and Education. 2023;4(11).
Daminov Abdurasul Takhirovich RSU. FEATURES OF THE CLINIC, REHABILITATION, TREATMENT OF AUTOIMMUNE THYROIDITIS IN THE CONDITIONS OF THE IODINE-DEFICIENCY REGION. Published online April 12, 2023. doi:10.5281/ZENODO.7820412
Shuhratovna NG, Shukhratovna SD. Features of the course of autoimmune hepatitis in children as a variant of autoimmune polyglandular syndrome. Asia Journ of Multidimensi Resear (AJMR). 2020;9(7):89. doi:10.5958/2278-4853.2020.00228.1
Erkinovna SD. Features of the Course of Diabetes Mellitus Type 2 with Arterial Hypertension. JournalNX. Published online 2020:460-461.
Takhirovich DA, Zafarovna KM, Isroilovna IS. FEATURES OF TYPE 1 DIABETES IN CHILDREN WHO HAVE COVID-19. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(9):121-123.
Xudoyorov S, Mirkomilova M, Burxonov U, Sayfieva G, Sheralieva N, Daminov AT. Fourniers gangrene in modern conditions. Science and Education. 2023;4(12):107-117.
Alimovna KN, Sobirjanovna KN, Abdurasul D, Tulkinovich OS. GROWTH HORMONE FOR THE TREATMENT OF HEREDITARY DISEASES IN CHILDREN. 10.
Negmatova .G.Sh, D.e S, Qizi MZO, Mannobovich MS, Orifjonovich MM. HERPETIC MENINGITIS. PEDAGOG. 2022;5(5):346-348.
Ahrorbek N, Myungjae L, Jungjae L, et al. Hormonal Regulation. Texa Jour of Mutl Stud. 2023;25:39-43.
Ismoilova SI. Impact of vitamin D deficiency on the risk of developing type 1 diabetes. Science and Education. 2023;4(3).
T DA, Umidbekovna UM, Muhitdinovna KN. Methodology of Using Modern Graphics Programs in Teaching Engineering Graphics. 1. Published online December 8, 2023:158-162.
Sabirjanovna KN, Takhirovich DA, Jahongir D, Najmiddin X, Samandar G, Mehrangiz X. Negative Impact of Covid-19 on the Endocrine System. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(8):148-153.
Takhirovich DA, Zafarovna KM, Isroilovna IS. NEVROLOGIYADA ENDOKRIN O‘ZGARISHLAR. SO‘NGI ILMIY TADQIQOTLAR NAZARIYASI. 2023;6(12):417-422.
Negmatova GS, Salimova DE. Qandli diabet 2-tipning arterial gipertenziya bilan birgalikda kechish xususiyatlari va ularni davolash usullari. Science and Education. 2023;4(2):516-519.
Taxirovich DA, J T, O E, I A. QANDLI DIABET-2 TIPI BOR BEMORLARDA COVID-19 KASALLIGINI GLUKOKORTIKOIDLAR BILAN DAVOLASH DINAMIKASINI BAHOLASH. Gospodarka i Innowacje. 2023;34:78-81.
G.Sh N, D.e S, Alisherovich BA, Erkin R is the son of S, Bektash U is the son of S. RELATIONSHIP BETWEEN DIABETIC NEPHROPATHY AND CARDIAC DISORDERS IN PATIENTS WITH TYPE 2 DIABETES. PEDAGOG. 2022;5(5):337-340.
Shukhratovna NG, Erkinovna SD, Oʻgʻli IBI, Qizi ADD. THE ROLE OF GASTROINTESTINAL HORMONES IN THE PATHOLOGY OF THE DIGESTIVE SYSTEM. PEDAGOG. 2022;5(6):408-412.
Ulugbekovna NP, Bakhtiyorovna RI, Almosovich RA, Takhirovich DA. Thyroid Diseases during Pregnancy and their Impact on Maternal and Fetal Outcomes. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(8):188-190.
Nilufar R, Adkhamjon K. TO THE DEVELOPMENT OF CARDIOVASCULAR DISEASES EFFECTS OF ENVIRONMENTAL FACTORS. FAN, TA’LIM, MADANIYAT VA INNOVATSIYA JURNALI | JOURNAL OF SCIENCE, EDUCATION, CULTURE AND INNOVATION. 2022;1(4):100-101.
Xoldorov X, Omonov F, Jumayev I, Daminov AT. TYPE 1 DIABETES AS A RISK FACTOR FOR BONE HEALTH IN CHILDHOOD. Results of National Scientific Research International Journal. 2023;2(8):131-135.
Daminov AT, Xurramova S, Islomov A, Ulashev M, Ikramov R, Mirzakhakimov P. Type 2 diabetes and bone mineral density in postmenopausal women. Science and Education. 2023;4(11).
Berkinov A, Safarov F, Tursunova S, Daminov AT. VITAMIN D STATUS IN SENIOR RESIDENTS OF SAMARKAND REGION. Results of National Scientific Research International Journal. 2023;2(8):136-140.
Taxirovich DA, N SY, I IM, Z SM. VITAMIN-D YETISHMOVCHILIGINING QANDLI DIABET 1-TIP RIVOJLANISHIGA TA’SIRI. Gospodarka i Innowacje. 2023;34:74-77.
