CLINICAL OBSERVATION OF SEVERE ITSENKO-CUSHING DISEASE
Keywords:
Itsenko-Cushing‘s disease, clinical observation, hypercorticism, hypercortisolemia, ACTH, somatostatin receptor scintigraphy, transsphenoidaladenomectomy.Abstract
Itsenko-Cushing disease is a serious disease of the neuroendocrine system caused by excessive release of adrenocorticotropic hormone by a pituitary tumor. The incidence of this disease is 39.1 cases per 1 million population, and the incidence is from 1.2 to 2.4 cases per 1 million. Typical symptoms include rapid weight gain combined with muscle weakness, hypertension, diabetes mellitus and osteoporosis . The main diagnostic method is MRI of the brain after laboratory confirmation of hypercortisolemia, and the main treatment method is transnasaladenomectomy, which allows achieving remission in 65–90% of cases. This article describes a clinical observation of severe Itsenko-Cushing disease, which remained undiagnosed for a long time. The stages of the diagnostic search, the difficulties of differential diagnosis and the results of dynamic observation, including selective blood sampling from the inferior petrosal sinuses are considered. A multidisciplinary approach and teamwork make it possible to ensure timely diagnosis, prevent the development of complications of Itsenko-Cushing disease, and improve the patient’s prognosis and quality of life.
References
Отамуродов УГ угли, Абдужамбилов АН угли, Сабирова ДШ. Гипертиреоз. ScienceandEducation. 2023;4(5):134-139.
Шухратовна СД, Рустамовна РГ, Нодир Р. Изменения уровня хг в системе мать-плацента-плод прирезус несовместимой беременности. Достижения науки и образования. 2020;(10 (64)):91-93.
Хамраев X, Содиков С, Хамраева Д, Собирова Д. Клинико-функциональное состояние печени у больных с сахарным диабетом. ЖПБМ. 2018;(1 (99)):189-191.
Shukhratovna SD, Suratovich OF. МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ КОРЫ НАДПОЧЕЧНИКОВ ПОТОМСТВА КРЫС В ОНТОГЕНЕЗЕ В УСЛОВИЯХ ВНУТРИУТРОБНОГО ВОЗДЕЙСТВИЯ ПЕСТИЦИДОВ ЧЕРЕЗ ОРГАНИЗМ МАТЕРИ (ОБЗОРНАЯ СТАТЬЯ). JOURNAL OF BIOMEDICINE AND PRACTICE. 2023;8(4). Accessed January 12, 2024. https://tadqiqot.uz/index.php/biomedicine/article/view/8217
Мизамова МАК, Эшпулатова ГНК, Эшмуродова ЗНК, Салимова ДЭ. Осложнения акромегалии, связанные со здоровьем, текущие и перспективные варианты лечения. ScienceandEducation. 2023;4(4):187-195.
Нарбаев А, Джураева З, Курбонова Н, Кувондиков Г, Давранова А, Содиков С. Особенности изучения многофакторного управления сахарным диабетом 2 типа. Журнал проблемы биологии и медицины. 2017;(4 (97)):78-79.
Ибрагимов УС, Туракулов ЖТУ, Гуломов ШНУ, Салимова ДЭ. Просвещение пациентов: Гипогликемия (низкий уровень глюкозы в крови) у людей с диабетом. ScienceandEducation. 2023;4(4):226-233.
Содиков С, Каримова Н, Каримова З. Реабилитация больных пожилого возраста сахарным диабетом 2-типа. ЖПБМ. 2017;(4 (97)):105-106.
Хамидова МН, Исматова ИФ, Бердиеров ЖШ, Негматова ГШ, Даминов АТ. САХАРНЫЙДИАБЕТИ COVID-19. Eurasian Journal of Medical and Natural Sciences.2022;2(13):190-204.
Шухратовна СД, Кахрамонович ЮУ, Махмудович КТ. Структурные изменения сосудисто-стромального комплекса щитовидной железы при эутиреоидной и токсических формах зоба. Научный журнал. 2019;(10 (44)):67-69.
Собиржоновна КН, Саллохидинович СС, Акбаровна ОМ. Эпидемиологический Статус И Факторы Риска Сахарного Диабета На Сегодняшний День. MiastoPrzyszłości. 2023;32:212-219.
Salimova DE, Daminnov AT. A CLINICAL CASE BASED ON THE EXPERIENCE OF TREATING HYPERTENSION IN A PATIENT WITH TYPE 2 DIABETES MELLITUS, OBESITY AND VITAMIN D DEFICIENCY. Educational Research in Universal Sciences. 2023;2(12):150-154.
Takhirovich DA. ASSESSMENT OF HEARING FUNCTION IN INDIVIDUALS WITH TYPE 2 DIABETES. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(9):124-126.
Qahramonov FA, Amirov BY, Tursunboyeva LI, Daminov AT. Autoimmuntireoiditbilankasallanganbemorlardagifunksionalbuzilishlarningdifferensionaldiagnostikasidaqalqonsimonbezzichliginianiqlash.Science and Education. 2023;4(3):82-86.
Nazira K, Siddikovna TG, Davranovna DA, Takhirovich DA, Tulkinovich OS. Cardiovascular complications in patients who have had covid on the background of diabetes mellitus 2.1. 2021;2(3):37-41.
Choriyev S, Gadoeva Z, Mardonova F, Jurakulov F, Hafizov S, Daminov AT. Changes in the thyroid gland in the long period after a new coronavirus infection.Science and Education. 2023;4(12):102-106.
Kamalov T, Bahriev N, Yuldashev U, Sabirova D. CLINICAL AND HORMONAL CHARACTERISTICS OF PRIMARY HYPOGONADISM IN PRESCHOOL BOYS. MedFarm. 2019;10(9). doi:10.32743/2658-4093.2019.9.10.188
Daminov A, Khaydarov O, Hasanova M, Abdukakhorova R. COMPLICATIONS OF GLUCOCORTICOID THERAPY IN PATIENTS DIABETES SURVIVED COVID-19. Евразийскийжурналмедицинскихиестественныхнаук. 2023;3(4):197-200.
Takhirovich DA, Corners SJA, Shukhratovna NG, Shukhratovna SG, Zaynuddinovna MG. COURSE OF COVID-19 IN PATIENTS WITH DIABETES MELLITUS. Web of Scientist: International Scientific Research Journal. 2022;3(02):73-76. doi:10.17605/OSF.IO/B6FU2
Shukhratovna NG, Erkinovna SD, Suxrobovna XM, Ikromovna AZ. DIABETES MELLITUS, ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION. PEDAGOG. 2022;5(5):381-386.
O‘g‘li SOS, O‘g‘li RSO, Taxirovich DA. DIFFUZTOKSIKBUQOQ. Лучшиеинтеллектуальныеисследования. 2023;4(1):131-133.
G.Sh N, D.e S, Oybekovma XS, Qamariddinovna XA, O‘g‘li BJA. ENDOCRINE GLANDS, STRUCTURE, AGE FEATURES, FUNCTIONS. PEDAGOG. 2022;5(5):341-345.
Sobirjonovna KN. FACTORS DETERMINING THE CLINICAL SIGNIFICANCE OF DEPIPTIDYL PEPTIDASE 4 INHIBITORS IN THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS. World Bulletin of Public Health. 2022;8:67-72.
Daminov AT, Djabbarova D, Abduvohidova N, Furkatova D, Farxodova S, Ibragimova P. Features of bone tissue remodeling in patients with type 2 diabetes mellitus. Science and Education. 2023;4(11).
DaminovAbdurasulTakhirovich RSU. FEATURES OF THE CLINIC, REHABILITATION, TREATMENT OF AUTOIMMUNE THYROIDITIS IN THE CONDITIONS OF THE IODINE-DEFICIENCY REGION.Published online April 12, 2023. doi:10.5281/ZENODO.7820412
Shuhratovna NG, Shukhratovna SD. Features of the course of autoimmune hepatitis in children as a variant of autoimmune polyglandular syndrome. Asia Journ of MultidimensiResear (AJMR). 2020;9(7):89. doi:10.5958/2278-4853.2020.00228.1
Erkinovna SD. Features of the Course of Diabetes Mellitus Type 2 with Arterial Hypertension. JournalNX.Published online 2020:460-461.
Takhirovich DA, Zafarovna KM, Isroilovna IS. FEATURES OF TYPE 1 DIABETES IN CHILDREN WHO HAVE COVID-19.American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(9):121-123.
Xudoyorov S, Mirkomilova M, Burxonov U, Sayfieva G, Sheralieva N, Daminov AT. Fourniers gangrene in modern conditions. Science and Education. 2023;4(12):107-117.
Alimovna KN, Sobirjanovna KN, Abdurasul D, Tulkinovich OS. GROWTH HORMONE FOR THE TREATMENT OF HEREDITARY DISEASES IN CHILDREN. 10.
Negmatova .G.Sh, D.e S, Qizi MZO, Mannobovich MS, Orifjonovich MM. HERPETIC MENINGITIS. PEDAGOG. 2022;5(5):346-348.
Ahrorbek N, Myungjae L, Jungjae L, et al. Hormonal Regulation. Texa Jour of Mutl Stud. 2023;25:39-43.
Ismoilova SI. Impact of vitamin D deficiency on the risk of developing type 1 diabetes.Science and Education. 2023;4(3).
T DA, Umidbekovna UM, Muhitdinovna KN. Methodology of Using Modern Graphics Programs in Teaching Engineering Graphics. 1. Published online December 8, 2023:158-162.
Sabirjanovna KN, Takhirovich DA, Jahongir D, Najmiddin X, Samandar G, Mehrangiz X. Negative Impact of Covid-19 on the Endocrine System. American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(8):148-153.
Takhirovich DA, Zafarovna KM, Isroilovna IS. NEVROLOGIYADA ENDOKRIN O‘ZGARISHLAR.SO‘NGI ILMIY TADQIQOTLAR NAZARIYASI. 2023;6(12):417-422.
Negmatova GS, Salimova DE. Qandlidiabet 2-tipning arterial gipertenziyabilanbirgalikdakechishxususiyatlarivaularnidavolashusullari. Science and Education. 2023;4(2):516-519.
Taxirovich DA, J T, O E, I A. QANDLI DIABET-2 TIPI BOR BEMORLARDA COVID-19 KASALLIGINI GLUKOKORTIKOIDLAR BILAN DAVOLASH DINAMIKASINI BAHOLASH. Gospodarka i Innowacje. 2023;34:78-81.
G.Sh N, D.e S, Alisherovich BA, Erkin R is the son of S, Bektash U is the son of S. RELATIONSHIP BETWEEN DIABETIC NEPHROPATHY AND CARDIAC DISORDERS IN PATIENTS WITH TYPE 2 DIABETES. PEDAGOG. 2022;5(5):337-340.
Shukhratovna NG, Erkinovna SD, Oʻgʻli IBI, Qizi ADD. THE ROLE OF GASTROINTESTINAL HORMONES IN THE PATHOLOGY OF THE DIGESTIVE SYSTEM.PEDAGOG. 2022;5(6):408-412.
Ulugbekovna NP, Bakhtiyorovna RI, Almosovich RA, Takhirovich DA. Thyroid Diseases during Pregnancy and their Impact on Maternal and Fetal Outcomes.American Journal of Pediatric Medicine and Health Sciences (2993-2149). 2023;1(8):188-190.
